Enteroviruses and diabetes

Viruses and Type 1 Diabetes: Focus on the Enteroviruses

Enteroviruses and Type 1 Diabetes: Candidate Genes Linked With Innate Immune Response

In addition to HLA associated genetic predisposition, the role of In addition, PTPN2, a candidate gene for T1D is a negative regulator exogenous factors in the development of type 1 diabetes (T1D) is well admitted. Since many decades, accumulating evidence strongly has supported an association between enteroviruses (EV) and T1D (Hober and Sauter, 2010). Moreover, the potential mechanisms underl...

The enteroviruses: recent advances.

New information accrues periodically in the ledger accounting for infections and diseases associated with the human enteroviruses. The discoveries of "new" serotypes and how they affect people are subjects of continuing attention. Some other relevant information on "old" serotypes relates to variations in age-specific attack rates and associated morbidity and mortality for neonates and older in...

Replication and Inhibitors of Enteroviruses and Parechoviruses

The Enterovirus (EV) and Parechovirus genera of the picornavirus family include many important human pathogens, including poliovirus, rhinovirus, EV-A71, EV-D68, and human parechoviruses (HPeV). They cause a wide variety of diseases, ranging from a simple common cold to life-threatening diseases such as encephalitis and myocarditis. At the moment, no antiviral therapy is available against these...

Therapeutic Use of Native and Recombinant Enteroviruses.

Research on human enteroviruses has resulted in the identification of more than 100 enterovirus types, which use more than 10 protein receptors and/or attachment factors required in cell binding and initiation of the replication cycle. Many of these "viral" receptors are overexpressed in cancer cells. Receptor binding and the ability to replicate in specific target cells define the tropism and ...